site > International journal > (2009) Assembly of coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle.

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작성일 : 12-07-17 18:10

(2009) Assembly of coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle.

글쓴이 : 박용철

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http://www.sciencedirect.com/science/article/pii/S0006291X09015137 [1200]

Assembly of coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle.

Jae-Yoon Shin, Jae-Il Shin, Jun-Seob Kim, Yoo-Soo Yang, Yun-Ha Hwang, Joo-Sung Yang, Dongwoo Shin, Jin-Ho Seo, Yong-Su Jin, Yong-Cheol Park, Jae-Sung Hwang and Dae-Hyuk Kweon*
Biochemical and Biophysical Research Communications 388: 217-221 2009.10.16.
(SCI/IF: 2.484)

There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that CoenzymeQ10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascentdiscoidalhighdensitylipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of ∼12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates.

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