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작성일 : 13-01-02 10:53

(2013, IF=1.381) Effects of oxygen supply and mixed sugar concentration on D-ribose production by a transketolase-deficient Bacillus subtilis SPK1

글쓴이 : ycpark

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http://www.jmb.or.kr/submission/File/201212/121084/JMB12-12021_Galley.… [552]

Effects of oxygen supply and mixed sugar concentration on D-ribose production by a transketolase-deficient Bacillus subtilis SPK1

Yong-Cheol Park*, Hye-Jin Lee, Chang-Sup Kim and Jin-Ho Seo

Journal of Microbiology and Biotechnology vol.23, no.4, page 555-559, 2013.04.28 (SCIE IF = 1.381)

Abstract
D-Ribose is a value-added five-carbon sugar used for riboflavin production. To investigate the effects of oxygen supply and mixed sugar concentration on microbial production of D-ribose, a transketolase-deficient Bacillus subtilis SPK1 was cultured batch-wise using xylose and glucose. Change of agitation speed from 300 rpm to 600 rpm at 1 vvm of air supply increased both xylose consumption rate and D-ribose production rate. Because a sum of the specific consumption rates for xylose and glucose was similar at all agitation speeds, metabolic preferences between xylose and glucose might depend on oxygen supply. Although B. subtilis SPK1 can uptake xylose and glucose by the active transport mechanism, high initial concentration of xylose and glucose was not beneficial for high D-ribose production.

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