site > International journal > (2017, IF=3.376) Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production

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작성일 : 17-02-03 10:49

(2017, IF=3.376) Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production

글쓴이 : ycpark

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https://link.springer.com/article/10.1007%2Fs00253-017-8172-1 [407]

Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production

Soo-Jung Kim, Jin-Woo Kim, Ye-Gi Lee, Yong-Cheol Park and Jin-Ho Seo

Applied Microbiology and Biotechnology 101(6):2241-2250 (2017.03)

Saccharomyces cerevisiae is a work horse for production of valuable biofuels and biochemicals including 2,3-butanediol (2,3-BDO), a platform chemical with wide industrial applications for synthetic rubber, biosolvents and food additives. Recently, a cutting-edge technology of metabolic engineering has enabled S. cerevisiae to produce 2,3-BDO with high yield and productivity. These include (i) amplification of the 2,3-BDO biosynthetic pathway, (ii) redirection of carbon flux from ethanol or glycerol toward 2,3-BDO, and (iii) 2,3-BDO production from sugars derived from renewable biomass. These breakthroughs enforced S. cerevisiae to become a promising microbial host for production of 2,3-BDO.

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